Now Available: Compounded Oral Semaglutide for Sublingual Administration

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained prominence for its efficacy in managing type 2 diabetes and aiding weight loss. Traditionally administered via injection, semaglutide has shown significant benefits in glycemic control and weight management. However, recent advancements have introduced a compounded sublingual (liquid) form, which presents advantages over the injectable form.

What is Compounded Sublingual Semaglutide?

Compounded sublingual semaglutide is a custom-made formulation prepared by compounding pharmacies. Unlike the standard injectable semaglutide, this formulation is designed to be administered sublingually (under the tongue). The sublingual route allows the medication to be absorbed directly into the bloodstream through the mucous membranes, bypassing the digestive system.


Suggested Dosage

The dosage of compounded sublingual semaglutide can vary depending on the patient’s needs and the prescribing physician’s recommendations. Typically, the dosages mirror those of the injectable form, starting at lower doses and gradually increasing. For instance, initial doses may start at 0.25 g, with potential increments up to 1.0 mg or higher, depending on the therapeutic response and tolerability. 

A Problem Solved: Our Compounding Pharmacist Can Make a Highly Absorbable Semaglutide Product, Taken in Oral Form (not an injectable)!

At Towne Lake Pharmacy, we use a special base and our skill of years of formulating customized medications to compound our sublingual version of semaglutide. This allows for increase bioavailability of the drug into the body.

Which is Better for You: Sublingual (Under the tongue) Or Injectable (Needle)  Does Sublingual Semaglutide Differ from Injectable Semaglutide?

  1. Administration and Absorption:
  • Injectable Semaglutide: Administered subcutaneously, meaning the drug is injected into the fatty tissue under the skin. This method provides a slow and steady release of the medication into the bloodstream.
  • Sublingual Semaglutide: Placed under the tongue, where it dissolves and is absorbed directly into the bloodstream. This method can potentially offer a faster onset of action as it bypasses the gastrointestinal tract and first-pass metabolism in the liver.
  1. Patient Convenience and Compliance:
  • Injectable Semaglutide: Requires the use of needles and proper injection technique, which can be a barrier for some patients due to discomfort or needle phobia.
  • Sublingual Semaglutide: Eliminates the need for injections, potentially improving patient adherence and comfort. The ease of administration can be particularly beneficial for those who are averse to injections.

Potential Benefits

  1. Improved Patient Compliance: The non-invasive nature of sublingual administration can enhance adherence to the treatment regimen.
  2. Rapid Absorption: Direct entry into the bloodstream can lead to quicker onset of action.
  3. Avoidance of Gastrointestinal Disturbances: By bypassing the digestive system, sublingual administration may reduce gastrointestinal side effects, which are common with oral medications.


Compounded sublingual semaglutide represents a promising alternative to injectable semaglutide, offering a non-invasive route of administration that can enhance patient comfort and compliance. As research progresses, compounded sublingual semaglutide could become a valuable option in the management of type 2 diabetes and obesity, expanding the therapeutic possibilities for patients and healthcare providers.

  • Sublingual: No Shots, No Needles!
  • No Refrigeration Needed
  • No Supply Issues: We Make It Here!
  • Sublingual Drug Delivery Study Attached Below

A recent in vitro study demonstrated the ability of our compounding base to deliver semaglutide into and through human gingival and oral tissues. (read article here)

Compounded Semaglutide 1mg/0.5ml liquid
Direction for Use- 0.5ml under the tongue daily. Dispensed Qty: 15ml

Compounded Semaglatide 2mg/0.5ml liquid
Direction for Use- 0.5ml under the tongue daily. Dispensed Qty: 15ml

Compounded Semaglatide 3mg/0.5ml liquid
Direction for Use- 0.5ml under the tongue daily. Dispensed Qty: 15ml